產(chǎn)品描述

Recombinant Human Matrix Metalloproteinase-3 is produced by our Mammalian expression system and the target gene encoding Tyr18-Cys477 is expressed with a 6His tag at the C-terminus.The proenzyme needs to be activated by Chymotrypsin for an activated form.

蛋白編號(hào)

AAA36321.1

產(chǎn)品別稱

Stromelysin-1; SL-1; Matrix metalloproteinase-3; MMP-3; Transin-1; MMP3; STMY1

分子量

53.26 KDa

表觀分子量

50-65 KDa, reducing conditions

劑型描述

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 0.05% Brij35, 10% Glycerol, pH 7.5.

內(nèi)毒素

Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test.

純度-SDS-PAGE

Greater than 95% as determined by reducing SDS-PAGE. (QC verified)

保存條件

Store at ≤-70°C, stable for 6 months after receipt.

Store at ≤-70°C, stable for 3 months under sterile conditions after opening.

Please minimize freeze-thaw cycles.

運(yùn)輸條件

The product is shipped  dry  packs.

Upon receipt, store it immediately at the temperature listed below.

產(chǎn)品背景

MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. The MMP-3 enzyme degrades collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 crucial in connective tissue remodeling.[3] The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.

僅供科研或生產(chǎn)使用，不可直接應(yīng)用于人體。